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Whilst the opiate receptor relies on G protein coupling for signal transduction, this receptor was found to make the most of arrestin activation for internalization on the receptor. Usually, the receptor promoted no other sign… Read More

Conolidine’s analgesic consequences stem from its interaction with non-opioid pain pathways. Unlike opioids, which bind to µ-opioid receptors within the central nervous system, conolidine modulates alternate molecular targets.… Read More

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